產品名稱：美國小鼠Nurr1可誘導表達穩定細胞株

Introduction:

Nuclear hormone receptors (NHRs) are a superfamily of transcription factors that function as powerful metabolic regulators to control a variety of systemic processes in physiology. They also play key roles in the pathophysiology of many major disease states, such as diabetes, obesity, inflammation, atherosclerosis and heart failure. To date, this superfamily has provided a rich source of drug design targets and it is continuing to be one of the hottest areas for pharmaceutical researches.

PrimCells now provides a comprehensive set of NHR expressing cell lines to the research community. These high-quality, flag-and/or HA-tagged NHR-expressing cell lines aim to facilitate further biochemical and molecular studies of their functions and hence encourage new strategies for drug design.

The mouse Nurr1 stable cell line was created by stable co-transfection of HEK293 cells with two plasmids expressing the bacterial Tet repressor (TetR) and the mouse Nurr1 protein with FLAG tag, respectively. Since the mouse Nurr1 gene is driven by a promoter containing two tetracycline operator (TeTO2) sites, its expression can be induced by doxycycline.

美國PrimCells品牌介紹
PrimCells是位於美國加州聖迭戈的一家**致力於細胞產品研發和解決方案提供的業內技術領導企業。
公司彙集了的生物醫藥技術專家，獨立開發了多項原代細胞和乾細胞相關的專有技術。 公司以“細胞研究的*優選擇”為宗旨，自主研發*過70種產品，填補了多個特種細胞市場的空白。例如其誘導性表達細胞庫和高效3D皮膚培養係統，皆為該類產品目前市場上少數的規模化供應商。此外，公司以高質量的數據與快速穩定的項目完成時間，長期為多家知名製藥公司提供解決方案，獲得用戶**讚譽。   
PrimCells產品線：

• 報告基因乾細胞        2. 原代細胞（含報告基因原代細胞）               3. 誘導性穩定細胞株

4. 人源重組蛋白               5.   型培養試劑      
PrimCells 解決方案
1.誘導性穩定細胞株開發 2. 原代細胞開發 3. 體外毒理和效能測試 4. 3D-皮膚培養
PrimCells合作夥伴及客戶:
A．生物製藥公司：輝瑞(Pfizer), 諾華(Novartis), 禮來(Eli2  Lilly),. Amgen, EMD Millipore, Regeneron等公司的毒理和醫藥研發部門
B．科研機構：冷泉港實驗室，哈佛醫學院, 麻省理工（MIT）,， UCSF, NYU, Salk, UIUC, USC等