Brain Infusion Cannula Kits
Many agents do not cross the blood-brain barrier sufficiently to evaluate their effects on the brain without delivering them locally. Cerebral injection is one local delivery method, but it can be challenging to deliver an effective dose in a physiologically compatible volume. In addition, the agent may not remain in the target location long enough to see an effect. For many compounds, local infusion directly into the brain is the only way to generate reliable data. ALZET pumps have been used in hundreds of published neuroscience studies to infuse agents, from growth factors to siRNA to psychoactive drugs and more, to the central nervous system. The ALZET Brain Infusion Kits are designed specifically for use with ALZET pumps for targeted delivery to the central nervous system. They can be used in two ways: Infusion into the cerebral ventricles exposes a wide variety of brain regions to the infusate via the cerebrospinal fluid, which bathes the brain. Direct microperfusion of discrete brain structures results in localized distribution of infusate in the target tissue. Each ALZET Infusion Kit includes materials for 10 brain infusions:   10 Brain Infusion Cannulae 10 Vinyl Catheter Tubes 40 Depth-Adjustment Spacers 1 Instruction Sheet Brain Infusion Cannula Kit #1: Dimensions (steel tube): ID=0.18mm, OD=0.36mm; Length below pedestal: 5mm; Penetration depths (adjust using spacers): 3-5mm (from skull surface); Material elbow stop, flange: Polycarbonate; Cannula Design: Narrow diameter w/suture grooves; Volume Inside Tube: 0.32 µl; Material: Polycarbonate; Dimensions (Height): 0.5mm; Material:(medical grade); Length: 15cm (approx.); ID: 0.36mm (± 0.08); OD: 1.14mm (± 0.08); Volume / 15cm: 56 µl (3.7µl/cm) (materials for 10) Material Tube: Stainless Steel; Gauge Tube: 28G Part No. 0004760         Brain Infusion Cannula Kit #2: Dimensions (steel tube): ID=0.18mm, OD=0.36mm; Length below pedestal: 5mm; Penetration depths (adjust using spacers): 3-5mm (from skull surface); Material elbow stop, flange: Polycarbonate; Cannula Design: low profile & wide base for skin closure & stability; Volume Inside Tube: 0.32 µl; Material:Dimensions (Height): 0.5mm; Material: Polyvinylchloride (medical grade); Length:ID: 0.36mm (± 0.08); OD: 1.14mm (± 0.08); Volume / 15cm: 56 µl (3.7µl/cm) (materials for 10) Material Tube: Stainless Steel; Gauge Tube: 28G Part No. 0008663         Brain Infusion Cannula Kit #3: Dimensions (steel tube): ID=0.16mm, OD=0.31mm; Length below pedestal: 3mm; Penetration depths (adjust using spacers): 1-3mm (from skull surface); Material elbow stop, flange: Polycarbonate; Cannula Design: low profile & wide base for skin closure & stability; Volume Inside Tube: 0.23 µl; Material:Dimensions (Height): 0.5mm; Material: Polyvinylchloride (medical grade); Length:ID: 0.36mm (± 0.08); OD: 1.14mm (± 0.08); Volume / 15cm: 56 µl (3.7µl/cm) (materials for 10) Material Tube: Stainless Steel; Gauge Tube: 30G Part No. 0008851

許多**不能充分穿過血腦屏障來評估它們對大腦的影響而不在局部傳遞它們。腦注射是一種局部遞送方法，但是在生理學上相容的體積中遞送有效劑量可能是具有挑戰性的。此外，代理可能不會長時間保留在目標位置以觀察效果。對於許多化合物，直接局部輸注到大腦是產生可靠數據的唯壹方法。 ALZET泵已被用於數百項已發表的神經科學研究，將生長因子，siRNA，精神活**物等藥劑注入**神經係統。 ALZET腦輸液套件專為與ALZET泵配合使用而設計，可有針對性地輸送至**神經係統。它們可以以兩種方式使用：

輸入腦室通過腦脊液向腦內注射各種大腦區域。

離散腦結構的直接微灌注導致輸注物在靶組織中的局部分布。

每個ALZET輸液套件包含10種腦輸液的材料：

10腦輸液針頭

10個乙烯基導管

40深度調整墊片

1說明書