Brain Infusion Cannula Kits
Many agents do not cross the blood-brain barrier sufficiently to evaluate their effects on the brain without delivering them locally. Cerebral injection is one local delivery method, but it can be challenging to deliver an effective dose in a physiologically compatible volume. In addition, the agent may not remain in the target location long enough to see an effect. For many compounds, local infusion directly into the brain is the only way to generate reliable data. ALZET pumps have been used in hundreds of published neuroscience studies to infuse agents, from growth factors to siRNA to psychoactive drugs and more, to the central nervous system. The ALZET Brain Infusion Kits are designed specifically for use with ALZET pumps for targeted delivery to the central nervous system. They can be used in two ways: Infusion into the cerebral ventricles exposes a wide variety of brain regions to the infusate via the cerebrospinal fluid, which bathes the brain. Direct microperfusion of discrete brain structures results in localized distribution of infusate in the target tissue. Each ALZET Infusion Kit includes materials for 10 brain infusions:   10 Brain Infusion Cannulae 10 Vinyl Catheter Tubes 40 Depth-Adjustment Spacers 1 Instruction Sheet Brain Infusion Cannula Kit #1: Dimensions (steel tube): ID=0.18mm, OD=0.36mm; Length below pedestal: 5mm; Penetration depths (adjust using spacers): 3-5mm (from skull surface); Material elbow stop, flange: Polycarbonate; Cannula Design: Narrow diameter w/suture grooves; Volume Inside Tube: 0.32 µl; Material: Polycarbonate; Dimensions (Height): 0.5mm; Material:(medical grade); Length: 15cm (approx.); ID: 0.36mm (± 0.08); OD: 1.14mm (± 0.08); Volume / 15cm: 56 µl (3.7µl/cm) (materials for 10) Material Tube: Stainless Steel; Gauge Tube: 28G Part No. 0004760         Brain Infusion Cannula Kit #2: Dimensions (steel tube): ID=0.18mm, OD=0.36mm; Length below pedestal: 5mm; Penetration depths (adjust using spacers): 3-5mm (from skull surface); Material elbow stop, flange: Polycarbonate; Cannula Design: low profile & wide base for skin closure & stability; Volume Inside Tube: 0.32 µl; Material:Dimensions (Height): 0.5mm; Material: Polyvinylchloride (medical grade); Length:ID: 0.36mm (± 0.08); OD: 1.14mm (± 0.08); Volume / 15cm: 56 µl (3.7µl/cm) (materials for 10) Material Tube: Stainless Steel; Gauge Tube: 28G Part No. 0008663         Brain Infusion Cannula Kit #3: Dimensions (steel tube): ID=0.16mm, OD=0.31mm; Length below pedestal: 3mm; Penetration depths (adjust using spacers): 1-3mm (from skull surface); Material elbow stop, flange: Polycarbonate; Cannula Design: low profile & wide base for skin closure & stability; Volume Inside Tube: 0.23 µl; Material:Dimensions (Height): 0.5mm; Material: Polyvinylchloride (medical grade); Length:ID: 0.36mm (± 0.08); OD: 1.14mm (± 0.08); Volume / 15cm: 56 µl (3.7µl/cm) (materials for 10) Material Tube: Stainless Steel; Gauge Tube: 30G Part No. 0008851

许多**不能充分穿过血脑屏障来评估它们对大脑的影响而不在局部传递它们。脑注射是一种局部递送方法，但是在生理学上相容的体积中递送有效剂量可能是具有挑战性的。此外，代理可能不会长时间保留在目标位置以观察效果。对于许多化合物，直接局部输注到大脑是产生可靠数据的唯壹方法。 ALZET泵已被用于数百项已发表的神经科学研究，将生长因子，siRNA，精神活**物等药剂注入**神经系统。 ALZET脑输液套件专为与ALZET泵配合使用而设计，可有针对性地输送至**神经系统。它们可以以两种方式使用：

输入脑室通过脑脊液向脑内注射各种大脑区域。

离散脑结构的直接微灌注导致输注物在靶组织中的局部分布。

每个ALZET输液套件包含10种脑输液的材料：

10脑输液针头

10个乙烯基导管

40深度调整垫片

1说明书